Semi solid dosage form Pharmaceutics notes

Semi-solids constitute a large proportion of the drug formulation. They are used as carriers for drugs that are topically delivered by way of the skin, rectal tissue, vagina, cornea, urethral membrane, nasal mucosa, and so on. Semi-solids dosage forms are advantageous for a wide variety of drug molecules in terms of their ease of use, rapid preparation and local delivery capabilities. There are a variety of dosage forms for semi-solid, each with unique characteristics, they can be applied on the affected area directly and the administration of this dosage form to be readily administered to patients of any age. Semi-solids dosage forms usually presented in the form of ointments, gels, creams and suppositories, and these dosage forms consist of one or more active ingredients that dissolved or uniformly dispersed in a suitable base and any suitable excipients.

The Advantages of Semi-solids Dosage Forms

• External use
• Reduce the possibility of side effects
• Avoid first-pass intestinal and liver metabolism.
• Patient compliance is increased

Five Unit Operation for Semi-solids Dosage Forms

• Mixing of liquids
• Mixing and blending of solid
• Mixing and blending of semisolid
• Dispersing
• Milling and size reduction of solid and semisolid